Home - Polygenic Risk Score analysis

Genomic Risk Prediction of Complex Diseases

Seamlessy in the Cloud

Allelica allows the computation of Polygenic Risk Score based on Thousands or Millions of genetic variants. Upload genotype data and Allelica performs QC, imputation, risk modelling and results visualisation.

For Clinical Genetics Labs

Offer your customers the latest PRS for clinical grade risk prediction. Upload your SNP array or NGS data and our software performs PRS analysis in a cloud architecture that is fully automated, GDPR-HIPAA compliant and certified as a Medical Device. Differentiate your clinic from the crowd, embrace data-driven healthcare and generate a new source of revenue.

For Researchers

You’re just two clicks away from your next PRS paper. Use our platform to perform the entire PRS pipeline, QC and imputation, without writing a single line of code. Run and compare the performance of the most cited PRS methods, such as LD-Pred and Clumping and Thresholding. Focus only on what really matters for your research project without the hassle of informatics.

For Pharmas

Stratify participants of your clinical trials according to their genomic diversity. Use our software to identify individuals at with different underlying risk so that you can target your trial population saving your company money and time while having a better trial outcome. A simple genotyping array unlocks precious information on your cohort, invaluable to follow up decision-making in the modern area of drug development.

Trusted Translational Genomics

Allelica has built the first cloud platform that allows you to perform Polygenic Risk Score (PRS) analysis without writing a single line of code. The cloud architecture is a secure and trusted environment that has been certified as a Medical Device and is GDPR and HIPAA complaint. We work with leading clinical genetics labs, pharmaceutical companies and research institutes to improve health care prevention for a large number of complex diseases. The cloud platform accepts as input genotyping array and NGS data, performs genomic prediction analysis with published PRS or with your newly developed PRS.

Validation and testing on the UKBiobank is performed with just two clicks.

Allelica is partnering with Merck to develop technologies for early diagnosis and prevention of heart failure.

"With this agreement, Merck confirms its strong commitment in advancing Science and Technology in the therapeutic area of cardiovascular disorders" Antonio Messina - Merck General Manager

The Latest from Allelica

Abstract accepted for presentation! Giordano Bottà CEO & Co-Founder of Allelica will describe how the risk of Coronary Artery Disease conferred by Low-Density Lipoprotein Cholesterol depends on our polygenic background. We're proud to be part of the largest European conference of cardiology. This year ESC will be completely digital. We hope you'll take the opportunity to remotely attend this great event and enjoy our talk.

Abstract accepted for oral presentation! We were excited to share the latest results on how the integration of a cutting edge Polygenic Risk Score in CAD absolute risk models improves their predictive power and reclassifies individuals in the correct risk categories. Due to COVID-19 pandemia the conference was cancelled. The virus did not allow us to meet in person, but it can't stop the sharing of knowledge and high quality science. The presentation will be available online in the next coming days.

Allelica presented at the Personalized and Precision Medicine International Conference – PEMED 2020 in Munchen the research study on the integration of Coronary Artery Disease Polygenic Risk Score in clinical risk models. This annual Personalized and Precision Medicine International Conference gathered the best experts in the field to meet and discuss with the aim of translating precision medicine into direct improvements in health care.

Allelica attended the GenomicsLive Conference in Basel, Switzerland - December 2019. The Europe’s leading conference designed to deliver diagnostics and digital technologies into the clinic. The event covered diagnostics, digital pathology and clinical aspects of precision medicine.

At the “ESC 2019 together with World Congress of Cardiology”, held in Paris in the first week of September 2019, Allelica presented the newly developed software to compute Polygenic Risk Score (PRS) for Coronary Artery Disease. The clinical value of integrating PRS in traditional risk models was also discussed.

Why you should choose Allelica

Made by scientists

Allelica software and algorithms have been developed thanks to a collaboration between scientists who carried out resarches at Oxford University and the University of Rome “La Sapienza”.