Resources

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Frontiers

Cost-effectiveness analysis of implementing polygenic risk score in a workplace cardiovascular disease prevention program

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Publication
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Circulation

Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background

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Publication
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Journal of the American Heart Association

Integrating a Polygenic Risk Score for Coronary Artery Disease as a RiskEnhancing Factor in the Pooled Cohort Equation: A Cost-Effectiveness Analysis Study

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Publication
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Nature

Mapping the human genetic architecture of COVID-19

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Publication
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Revolutionizing Cardiovascular Health in the Workplace: The Power of Preventive Genomics

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Webinar
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Guidance for the Clinical Implementation of Polygenic Risk Score Testing for Common Disease

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Webinar
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Polygenic Risk Scores the Future of Precision Medicine Challenges and Opportunities

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Webinar
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Polygenic Risk Scores for All

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Webinar
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Polygenic Risk Scores in Clinical Care Filling the Gap in Risk Assessments for Common Diseases

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Webinar
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Clinical Application of Polygenic Risk Scores

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Webinar
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Allelica White Paper: PRS for Coronary Artery Disease

Development and Validation of a Polygenic Risk Score for Coronary Artery Disease

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White Paper
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bioRxiv

Software as a Service for the Genomic Prediction of Complex Diseases

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White Paper
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medRxiv

Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategies

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White Paper
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Allelica White Paper: Multi Ancestry PRS for Coronary Artery Disease

Development and Validation of Multi-Ancestry Polygenic Risk Scores for Coronary Artery Disease

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White Paper
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Allelica Clinical Use Case Coronary Artery Disease PRS

This document outlines an approach for using a Polygenic Risk Score (PRS) in a Coronary Artery Disease (CAD) clinical pathway.

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Use Case
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Polygenic Risk Score for Breast Cancer: a Clinical Use Case

This document outlines an approach for using a Polygenic Risk Score (PRS) in a breast cancer clinical pathway.

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Use Case
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Allelica - Introduction to Polygenic Risk Score

Allelica - Introduction to Polygenic Risk Score

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Video
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The PREDICT Module

The PREDICT module equips genetics laboratories with a trusted software as a medical device for ancestry-informed PRS analysis and clinical-grade reporting.

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Video
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Cardiovascular disease in the workplace: how to leverage data-driven solutions to the biggest health challenge facing employers

In today’s fast-paced corporate landscape, the health and well-being of employees are paramount for sustained productivity and success. One of the most prevalent health challenges facing workplaces is cardiovascular disease, particularly...

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Blog posts
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Five Considerations for Selecting a Workplace Wellness Program: How to Achieve Strong ROI for Employers & Long-Term Benefits for Employees

In the fast-paced world of business, ensuring the well-being of employees has become a top priority for innovative employers. A successful wellness program not only fosters a culture of healthier and happier employees, but also yields impressive returns...

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Blog posts
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How to ensure lasting employee engagement in your workplace health program

Maintaining a healthy and engaged workforce is a cornerstone of a successful organization. Workplace health programs not only enhance the well-being of employees but also contribute to increased productivity, reduced absenteeism, and...

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Blog posts
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Using polygenic risk scores to enhance cardiovascular disease risk prediction

Cardiovascular diseases — a general term for a suite of diseases that affect the heart or blood vessels — account for one in three deaths globally and are a major drain on public health spending. Our risk of cardiovascular disease increases as we age...

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Blog posts
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How to superpower a clinical trial with PRS

Clinical trials are an essential part of the pharmaceutical industry, but they face many challenges. One of the significant obstacles is the high rate of failure, with over 90% of drug candidates that...

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Blog posts
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PRS & Shared Decision Making

A valid question that is often asked when discussing PRS implementation is “how will this information be used in clinical care in the absence of clinical guidelines for PRS”? One approach is to ensure PRS risk information is presented in a way that...

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Blog posts
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NSGC’s PRS Practice Resource: Your PRS one-stop shop

This year was kicked off by the publication of the NSGC Practice Resource for Clinical Counseling/Translation of Polygenic Scores, put together by Wand et al. — a stellar team of leaders in the PRS field.

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Blog posts
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PRS-powered disease risk reporting

We’ve previously written about how you can use Allelica’s DISCOVER software to build new polygenic risk scores (PRS) and to deploy them at scale with PREDICT. While a PRS provides…

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Blog posts
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Harnessing the power of PRS by combining standardized reporting with Allelica’s software

This week, scientists from the Clinical Genome Resource (ClinGen) Complex Disease Working Group and the Polygenic Score (PGS) Catalog published a paper in Nature introducing…

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Blog posts
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Understanding the link between genetics, cholesterol and coronary artery disease

Cardiovascular disease is the leading cause of death worldwide, with recent estimates putting the global death toll at around 18 million each year. It is also a major burden on populations and health systems, contributing to…

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Blog posts
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The PREDICT Module: Unlocking the power of genomics

In our previous articles on Allelica’s PRS pipeline, we ran through how you can use our DISCOVER module to build your own PRS for a disease or trait of interest, as well as how our VALIDATE module can be used to test the predictive power of…

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Blog posts
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The VALIDATE module: Quantifying the power of PRS

Essential testing of your PRS on an independent population. In our previous articles outlining Allelica’s PRS pipeline we described how users can impute genotype or…

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Blog posts
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The DISCOVER Module: Seamlessly building new polygenic risk scores

A user friendly, cloud-based computing solution to build state-of-the-art, publication ready polygenic risk scores. The DISCOVER moduleallows users to build their own polygenic risk…

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Blog posts
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The IMPUTE Module: Enriching Low-Coverage and Microarray data

Fast and scalable genome imputation of Low-Coverage WGS and Microarray data in just minutes. Allelica’s PRS pipeline is built around a set of interconnected modules…

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Blog posts
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Coronary Artery Disease: Predicting risk through genetics

Within the last two decades, and upon completion of the world’s largest biological project in 2003, interest in the human genome and its effect on…

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Blog posts
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Large Scale Genomics Datasets In the UK

We previously wrote about the enormous impact that the UK Biobank (UKBB) is having to translational research. Although the scientific outputs from this project are now beginning…

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Blog posts
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Genetics is actionable

In Allelica we’re very excited about the incredible advances that analyses of large DNA datasets are bringing to medicine. In addition to the increasingly…

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Blog posts
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Beyond BRCA

Vast quantities of human DNA have been sequenced for biomedical research and clinicians, researchers and innovators are now beginning to focus on the next phase of the genomic revolution: translating these data into tools...

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Blog posts
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Disease is Polygenic

In the late 19th Century, a Moravian monk named Gregor Mendel passed his time by running experiments cross-breeding different types of pea plant. Amongst his…

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Blog posts
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The UK Biobank: unleashing the power of genome

A central goal of preventative medicine is to identify the people most at risk of disease early enough that something can be done…

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Blog posts
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Allelica announces the release of the Allelica Precision Server for CLIA-compliant, on-premises analysis and clinical reporting of polygenic risk score, pharmacogenomics and carrier screening

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Press Release
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Allelica, SP BioMed Partner for Breast Cancer Polygenic Risk Score Study in Taiwan

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Press Release
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UAB Cardiogenomics Clinic and Allelica to perform polygenic risk score clinical implementation study

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Press Release
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Allelica Launches Ancestry-Specific Polygenic Risk Score Tests for Common Diseases as a Laboratory-Developed Test

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Press Release
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Allelica's Health Economics Study Demonstrates Cost Savings of Polygenic Risk Score in Heart Attack Prevention

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Press Release
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Allelica Collaborates with Invitae to Build Ancestry-Informed Polygenic Risk Score for Breast Cancer

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Press Release
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Allelica Joins Forces with Leader in Genotyping Technology to Enable Polygenic Risk Score

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Press Release
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Yale School of Medicine Researcher Selects Allelica to Expand Polygenic Risk Score Research on Childhood Neuropsychiatric Disorders

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Press Release
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Allelica, the Leader in Polygenic Risk Scoring, Expands Scientific Advisory Board

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Press Release
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The University of Sydney secured a AU$1.4M grant plus AU$2M from industry and partners with Allelica, Inc. to advance heart disease prevention strategies through Polygenic Risk Score application

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Press Release