Resources

img

Circulation

Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein Cholesterol Depends on Polygenic Background

Read more
Publication
img

Journal of the American Heart Association

Integrating a Polygenic Risk Score for Coronary Artery Disease as a RiskEnhancing Factor in the Pooled Cohort Equation: A Cost-Effectiveness Analysis Study

Read more
Publication
img

Nature

Mapping the human genetic architecture of COVID-19

Read more
Publication
img

Polygenic Risk Scores for All

Polygenic Risk Scores for All

See the webinar
Webinar
img

Polygenic Risk Scores the Future of Precision Medicine Challenges and Opportunities

Polygenic Risk Scores the Future of Precision Medicine Challenges and Opportunities

See the webinar
Webinar
img

Polygenic Risk Scores in Clinical Care Filling the Gap in Risk Assessments for Common Diseases

Polygenic Risk Scores in Clinical Care Filling the Gap in Risk Assessments for Common Diseases

See the webinar
Webinar
img

Clinical Application of Polygenic Risk Scores

Clinical Application of Polygenic Risk Scores

See the webinar
Webinar
img

Allelica White Paper: PRS for Coronary Artery Disease

Development and Validation of a Polygenic Risk Score for Coronary Artery Disease

Read more
White Paper
img

bioRxiv

Software as a Service for the Genomic Prediction of Complex Diseases

Read more
White Paper
img

medRxiv

Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategies

Read more
White Paper
img

Allelica White Paper: Multi Ancestry PRS for Coronary Artery Disease

Development and Validation of Multi-Ancestry Polygenic Risk Scores for Coronary Artery Disease

Read more
White Paper
img

Allelica Clinical Use Case Coronary Artery Disease PRS

This document outlines an approach for using a Polygenic Risk Score (PRS) in a Coronary Artery Disease (CAD) clinical pathway.

Read more
Use Case
img

Polygenic Risk Score for Breast Cancer: a Clinical Use Case

This document outlines an approach for using a Polygenic Risk Score (PRS) in a breast cancer clinical pathway.

Read more
Use Case
img

Allelica - Introduction to Polygenic Risk Score

Allelica - Introduction to Polygenic Risk Score

Watch the video
Video
img

The PREDICT Module

The PREDICT module equips genetics laboratories with a trusted software as a medical device for ancestry-informed PRS analysis and clinical-grade reporting.

Watch the video
Video
img

PRS-powered disease risk reporting

We’ve previously written about how you can use Allelica’s DISCOVER software to build new polygenic risk scores (PRS) and to deploy them at scale with PREDICT. While a PRS provides…

Read more
Blog posts
img

Harnessing the power of PRS by combining standardized reporting with Allelica’s software

This week, scientists from the Clinical Genome Resource (ClinGen) Complex Disease Working Group and the Polygenic Score (PGS) Catalog published a paper in Nature introducing…

Read more
Blog posts
img

Understanding the link between genetics, cholesterol and coronary artery disease

Cardiovascular disease is the leading cause of death worldwide, with recent estimates putting the global death toll at around 18 million each year. It is also a major burden on populations and health systems, contributing to…

Read more
Blog posts
img

The PREDICT Module: Unlocking the power of genomics

In our previous articles on Allelica’s PRS pipeline, we ran through how you can use our DISCOVER module to build your own PRS for a disease or trait of interest, as well as how our VALIDATE module can be used to test the predictive power of…

Read more
Blog posts
img

The VALIDATE module: Quantifying the power of PRS

Essential testing of your PRS on an independent population. In our previous articles outlining Allelica’s PRS pipeline we described how users can impute genotype or…

Read more
Blog posts
img

The DISCOVER Module: Seamlessly building new polygenic risk scores

A user friendly, cloud-based computing solution to build state-of-the-art, publication ready polygenic risk scores. The DISCOVER moduleallows users to build their own polygenic risk…

Read more
Blog posts
img

The IMPUTE Module: Enriching Low-Coverage and Microarray data

Fast and scalable genome imputation of Low-Coverage WGS and Microarray data in just minutes. Allelica’s PRS pipeline is built around a set of interconnected modules…

Read more
Blog posts
img

Coronary Artery Disease: Predicting risk through genetics

Within the last two decades, and upon completion of the world’s largest biological project in 2003, interest in the human genome and its effect on…

Read more
Blog posts
img

Large Scale Genomics Datasets In the UK

We previously wrote about the enormous impact that the UK Biobank (UKBB) is having to translational research. Although the scientific outputs from this project are now beginning…

Read more
Blog posts
img

Genetics is actionable

In Allelica we’re very excited about the incredible advances that analyses of large DNA datasets are bringing to medicine. In addition to the increasingly…

Read more
Blog posts
img

Beyond BRCA

Vast quantities of human DNA have been sequenced for biomedical research and clinicians, researchers and innovators are now beginning to focus on the next phase of the genomic revolution: translating these data into tools...

Read more
Blog posts
img

Disease is Polygenic

In the late 19th Century, a Moravian monk named Gregor Mendel passed his time by running experiments cross-breeding different types of pea plant. Amongst his…

Read more
Blog posts
img

The UK Biobank: unleashing the power of genome

A central goal of preventative medicine is to identify the people most at risk of disease early enough that something can be done…

Read more
Blog posts
img

UAB Cardiogenomics Clinic and Allelica to perform polygenic risk score clinical implementation study

Read more
Press Release
img

Allelica Launches Ancestry-Specific Polygenic Risk Score Tests for Common Diseases as a Laboratory-Developed Test

Read more
Press Release
img

Allelica's Health Economics Study Demonstrates Cost Savings of Polygenic Risk Score in Heart Attack Prevention

Read more
Press Release
img

Allelica Collaborates with Invitae to Build Ancestry-Informed Polygenic Risk Score for Breast Cancer

Read more
Press Release
img

Allelica Joins Forces with Leader in Genotyping Technology to Enable Polygenic Risk Score

Read more
Press Release
img

Yale School of Medicine Researcher Selects Allelica to Expand Polygenic Risk Score Research on Childhood Neuropsychiatric Disorders

Read more
Press Release
img

Allelica, the Leader in Polygenic Risk Scoring, Expands Scientific Advisory Board

Read more
Press Release
img

The University of Sydney secured a AU$1.4M grant plus AU$2M from industry and partners with Allelica, Inc. to advance heart disease prevention strategies through Polygenic Risk Score application

Read more
Press Release